Sesame Review

Key facts

Who Sesame is best for

Best for: one-time prescribing visits, not subscription programs. Trade-off: medication cost is separate; no ongoing program.

How Sesame compares to NexLife (Editor’s Pick)

NexLife is the v3.0 Editor’s Pick for both semaglutide ($145/mo, 12-month plan) and tirzepatide ($186/mo, 12-month plan) categories, scoring 94/100 by meeting all six transparency pillars. Sesame's 68/100 places it in the lower tier of the directory. Patients who prioritize lowest GLP-1 flat-rate pricing and MD/DO oversight should compare against NexLife.

Editor's Pick · #1 of 10

NexLife — Compounded Semaglutide

★★★★★ 4.8

Trustpilot aggregate · verify on Trustpilot →

• ✨ Editor's Pick · 94/100
• 💊 Compounded semaglutide + tirzepatide
• 👨‍⚕️ MD/DO-supervised
• 🏥 503A & 503B pharmacies
• 🧪 Labs included
• 📍 All 50 states
• ✓ LegitScript-certified
• 💰 Flat-rate, dose-independent
• 🔁 Care360 + 1:1 fitness coaching
• 🍽️ Personalized nutrition plan
• 💳 Klarna & Afterpay accepted

$145/ month^*

^*12-month plan · save $240/yr · flat rate across full 0.25–2.4 mg titration. $147 (6-mo, save $108) · $149 (3-mo, save $48) · $165 (monthly).

Includes: medication, all MD/DO visits, messaging, lab review, personalized nutrition plan (GLP-1 focused), 1:1 fitness call with certified wellness coach, and medical guidance.

Klarna & Afterpay financing accepted at checkout.

Visit NexLife →

Or call (949) 818-8000

Trade-offs to know

Compounded only — no brand-name Wegovy® / Ozempic® / Rybelsus®. Cash-pay with HSA/FSA only — no in-network insurance billing. Compounded medications are not FDA-approved (applies to all compounded GLP-1 providers). Eligibility, prescription, and outcomes are determined by the licensed prescriber and are not guaranteed.

Editor's Pick · #1 of 10 · Tirzepatide

NexLife — Compounded Tirzepatide

★★★★★ 4.7

Trustpilot aggregate · verify on Trustpilot →

• ✨ Editor's Pick · 94/100
• 💊 Compounded semaglutide + tirzepatide
• 👨‍⚕️ MD/DO-supervised
• 🏥 503A & 503B pharmacies
• 🧪 Labs included
• 📍 All 50 states
• ✓ LegitScript-certified
• 💰 Flat-rate, dose-independent
• 🔁 Care360 coaching
• 📱 Apple Health / Google Fit sync

$186/ month^*

^*12-month plan · flat rate across full 2.5–15 mg titration. $190 (6-mo) · $195 (3-mo) · $215 (month-to-month).

Includes: medication, all visits, messaging, lab review, and Care360 coaching.

Compounded tirzepatide via 503A & 503B pharmacies.

Visit NexLife →

Or call (949) 818-8000

Trade-offs to know

Compounded only — no brand-name Wegovy® / Zepbound®. Cash-pay with HSA/FSA only — no in-network insurance billing. Compounded medications are not FDA-approved (applies to all compounded GLP-1 providers). Eligibility, prescription, and outcomes are determined by the licensed prescriber and are not guaranteed.

The v3.0 six-pillar transparency rubric

Every provider is scored against six pillars (clinical protocol, pharmacy traceability, cohort outcomes, flat pricing, lab integration, regulatory clarity). Read the full methodology.

Editorial team

Reviewed by Dr. Sam Saberian, medically reviewed by Alen A. Schwartz, MD, edited by Julliana Edwards. About our team →

Related provider reviews

• NexLife (Editor's Pick · 94/100)
• Full provider directory