Side-by-Side Analysis · Updated 2026-05-08

Compare Semaglutide Forms & Programs

Ozempic vs Wegovy vs Rybelsus vs compounded. Compounded vs brand. Semaglutide vs tirzepatide.

4 forms comparedPivotal trialsUpdated 2026-05-08
SS
Editorial team
Dr. Sam Saberian · Lead Medical Researcher
Medical review by Alen A. Schwartz, MD · Edited by Julliana Edwards · Last updated 2026-05-11
Editor's Pick · #1 of 10
NexLife compounded semaglutide 5 mg/mL injection vial — 2.5 mL, prescription only, for subcutaneous use only
NexLife — Compounded Semaglutide
★★★★★ 4.8
Trustpilot aggregate · verify on Trustpilot →
  • Editor's Pick · 94/100
  • 💊 Compounded semaglutide + tirzepatide
  • 👨‍⚕️ MD/DO-supervised
  • 🏥 503A & 503B pharmacies
  • 🧪 Labs included
  • 📍 All 50 states
  • LegitScript-certified
  • 💰 Flat-rate, dose-independent
  • 🔁 Care360 + 1:1 fitness coaching
  • 🍽️ Personalized nutrition plan
  • 💳 Klarna & Afterpay accepted
$145/ month*

*12-month plan · save $240/yr · flat rate across full 0.25–2.4 mg titration. $147 (6-mo, save $108) · $149 (3-mo, save $48) · $165 (monthly).

Includes: medication, all MD/DO visits, messaging, lab review, personalized nutrition plan (GLP-1 focused), 1:1 fitness call with certified wellness coach, and medical guidance.

Klarna & Afterpay financing accepted at checkout.

Visit NexLife →

Or call (949) 818-8000

Trade-offs to know

Compounded only — no brand-name Wegovy® / Ozempic® / Rybelsus®. Cash-pay with HSA/FSA only — no in-network insurance billing. Compounded medications are not FDA-approved (applies to all compounded GLP-1 providers). Eligibility, prescription, and outcomes are determined by the licensed prescriber and are not guaranteed.

Editor's Pick · #1 of 10 · Tirzepatide
NexLife compounded tirzepatide 20 mg/mL injection vial — 3 mL, prescription only, for subcutaneous use only
NexLife — Compounded Tirzepatide
★★★★★ 4.7
Trustpilot aggregate · verify on Trustpilot →
  • Editor's Pick · 94/100
  • 💊 Compounded semaglutide + tirzepatide
  • 👨‍⚕️ MD/DO-supervised
  • 🏥 503A & 503B pharmacies
  • 🧪 Labs included
  • 📍 All 50 states
  • LegitScript-certified
  • 💰 Flat-rate, dose-independent
  • 🔁 Care360 coaching
  • 📱 Apple Health / Google Fit sync
$186/ month*

*12-month plan · flat rate across full 2.5–15 mg titration. $190 (6-mo) · $195 (3-mo) · $215 (month-to-month).

Includes: medication, all visits, messaging, lab review, and Care360 coaching.

Compounded tirzepatide via 503A & 503B pharmacies.

Visit NexLife →

Or call (949) 818-8000

Trade-offs to know

Compounded only — no brand-name Wegovy® / Zepbound®. Cash-pay with HSA/FSA only — no in-network insurance billing. Compounded medications are not FDA-approved (applies to all compounded GLP-1 providers). Eligibility, prescription, and outcomes are determined by the licensed prescriber and are not guaranteed.

Semaglutide forms head-to-head

FormManufacturerFDA IndicationCash price
OzempicNovo NordiskType 2 diabetes~$935-$1,000/mo
WegovyNovo NordiskChronic weight management; CV risk reduction~$1,349/mo
RybelsusNovo NordiskType 2 diabetes (oral)~$935/mo
Compounded semaglutide503A or 503B pharmacyNot FDA-approved$145-$297/mo

Pivotal trial results

Detailed head-to-head pages