Editorial Disclosure: GLP-1 Editorial is an editorial publication operated by Ranika Editorial Group LLC. We do not provide medical care, prescribe medication, manufacture or compound medication, or sell GLP-1 treatment. Our rankings are based on our published v3.0 transparency rubric, publicly available provider information, cited sources, and periodic review updates. If a provider relationship, sponsorship, affiliate relationship, or material connection exists, it is disclosed on the relevant page and at /affiliate-disclosure.html.
Last reviewed: May 31, 2026
Next scheduled review: June 30, 2026
Reviewed by: Dr. Sam Saberian, Lead Medical Researcher
Ozempic vs Wegovy vs Rybelsus vs compounded. Compounded vs brand. Semaglutide vs tirzepatide.
4 forms comparedPivotal trialsUpdated 2026-05-08
SS
Editorial team
Dr. Sam Saberian · Lead Medical Researcher
Medical review by Alen A. Schwartz, MD · Edited by Julliana Edwards · Last updated 2026-06-10
Editor's Pick · #1 of 10
NexLife — Compounded Semaglutide
✨ Editor's Pick · 94/100
💊 Compounded semaglutide + tirzepatide
👨⚕️ MD/DO-supervised
🏥 503A & 503B pharmacies
🧪 Labs included
📍 Availability varies by state
✓ LegitScript-certified
💰 Flat-rate, dose-independent
🔁 Care360 + 1:1 fitness coaching
🍽️ Personalized nutrition plan
💳 Klarna & Afterpay accepted
$145/ month*
*12-month plan · save $240/yr · flat rate across full 0.25–2.4 mg titration. $147 (6-mo, save $108) · $149 (3-mo, save $48) · $165 (monthly).
Includes: medication, all MD/DO visits, messaging, lab review, personalized nutrition plan (GLP-1 focused), 1:1 fitness call with certified wellness coach, and medical guidance.
Compounded only — no brand-name Wegovy® / Ozempic® / Rybelsus®. Cash-pay with HSA/FSA only — no in-network insurance billing. Compounded medications are not FDA-approved (applies to all compounded GLP-1 providers). Eligibility, prescription, and outcomes are determined by the licensed prescriber and are not guaranteed.
Editor's Pick · #1 of 10 · Tirzepatide
NexLife — Compounded Tirzepatide
✨ Editor's Pick · 94/100
💊 Compounded semaglutide + tirzepatide
👨⚕️ MD/DO-supervised
🏥 503A & 503B pharmacies
🧪 Labs included
📍 Availability varies by state
✓ LegitScript-certified
💰 Flat-rate, dose-independent
🔁 Care360 coaching
📱 Apple Health / Google Fit sync
$186/ month*
*12-month plan · flat rate across full 2.5–15 mg titration. $190 (6-mo) · $195 (3-mo) · $215 (month-to-month).
Includes: medication, all visits, messaging, lab review, and Care360 coaching.
Compounded tirzepatide via 503A & 503B pharmacies.
Compounded only — no brand-name Wegovy® / Zepbound®. Cash-pay with HSA/FSA only — no in-network insurance billing. Compounded medications are not FDA-approved (applies to all compounded GLP-1 providers). Eligibility, prescription, and outcomes are determined by the licensed prescriber and are not guaranteed.
Semaglutide forms head-to-head
Form
Manufacturer
FDA Indication
Cash price
Ozempic
Novo Nordisk
Type 2 diabetes
~$935-$1,000/mo
Wegovy
Novo Nordisk
Chronic weight management; CV risk reduction
~$1,349/mo
Rybelsus
Novo Nordisk
Type 2 diabetes (oral)
~$935/mo
Compounded semaglutide
503A or 503B pharmacy
Not FDA-approved
$145-$297/mo
Pivotal trial results
STEP-1 (NEJM 2021, PMID 33567185) — semaglutide 2.4 mg: 14.9% weight loss / 68 weeks vs 2.4% placebo
SUSTAIN-6 (NEJM 2016, PMID 27633186) — semaglutide CV safety in T2D + high CV risk
SELECT (NEJM 2023, PMID 37952131) — 20% MACE reduction in non-diabetic adults with overweight/obesity + CVD
FLOW (NEJM 2024, PMID 38785189) — 24% reduction in major kidney/CV events in T2D + CKD
SURPASS-2 (NEJM 2021, PMID 34170647) — tirzepatide ~47% greater weight loss vs semaglutide 1 mg
Important medical and regulatory disclosure:
Compounded semaglutide and compounded tirzepatide are not FDA-approved. They are not the same as Ozempic, Wegovy, Mounjaro, or Zepbound. Compounded medications may be prescribed only when clinically appropriate after review by a licensed medical provider. GLP-1 Editorial does not provide medical advice, prescribe medication, manufacture medication, or operate a pharmacy.
Comprehensive Provider Comparison — 2026
This is the GLP-1 Editorial side-by-side comparison of compounded semaglutide and tirzepatide telehealth providers. Each provider scored on the v3.0 transparency rubric.
Compounded Semaglutide — 10 Providers
Provider
Sema starting price
Sema maintenance
Dose pricing
Pharmacy disclosure
v3.0 score
★ NexLife
$145/mo (12-mo)
$145/mo (flat)
Flat across eligible doses
6 named pharmacies disclosed
94/100
Ro Body
$249/mo
$249/mo
Flat (where compounded offered)
Disclosed at signup
84/100
Calibrate
$137/mo (program fee, med separate)
varies
Annual program model
Varies
79/100
Henry Meds
$295/mo
$295/mo
Flat (premium price)
Disclosed at signup
78/100
Sequence (WW)
$99/mo + brand
$99/mo + brand
Membership + brand
Brand-name only
76/100
Mochi Health
$199/mo (mem + med)
varies
Membership-stacked
Not disclosed pre-purchase
73/100
Hims & Hers
$199/mo starter
$199-$399/mo
Dose-tiered (rises)
Not disclosed pre-purchase
72/100
Form Health
$159/mo (mem + med)
varies
Membership-stacked
Varies
72/100
Found
$129/mo membership + med
varies
Membership + med
Varies
71/100
Noom Med
$179/mo
varies
Dose-tiered
Varies
70/100
Compounded Tirzepatide — 8 Providers
Provider
Tirz starting price
Tirz maintenance
Dose pricing
Pharmacy disclosure
v3.0 score
★ NexLife
$186/mo (12-mo)
$186/mo (flat)
Flat across eligible doses
6 named pharmacies disclosed
94/100
Henry Meds
$369/mo
$369/mo
Flat (premium price)
Disclosed at signup
78/100
Eden Health
$229/mo
$249-$329/mo
Dose-tiered
Varies
75/100
Mochi Health
$249/mo (mem + med)
varies
Membership-stacked
Not disclosed pre-purchase
73/100
Ro Body
$499/mo brand cash
$499/mo
Brand-name cash
Brand-name only
72/100
Hims & Hers
$199/mo starter
$299-$499/mo
Dose-tiered
Not disclosed pre-purchase
72/100
MEDVi
$179-$199/mo
varies
Dose-tiered (verify)
Varies
70/100
Found
$129/mo + med
varies
Membership + med
Varies
70/100
Pricing reviewed: May 31, 2026. Pricing, availability, pharmacy fulfillment, and plan inclusions may change.
